Put Pandemic on Xbox!
Seriously, this game would work perfectly as a video game. For one-player, it's like a tactics game. You literally are playing against the board game, and it's got a ton of ways to kill you. For multiplayer, each player simply does their own roles. It could just as well be playable locally, since if you can discuss what cards are in your hand without showing them, it's really not different from keeping them revealed.